Two serious crashes occurred in the Limestone Coast over the long weekend.

A driver has been charged following one of the collisions Avenue Range, near Lucindale, just before 4pm on Friday.

Patrols and emergency crews were called to the intersection of Avenue Range Road and Crowder Road, Avenue Range, after two cars collided.

The driver and occupants of a Toyota SUV, a 40-year-old woman and two children, aged 7 and 9, sustained injuries and were taken to the Mount Gambier Hospital.

The driver was subsequently transported to the Royal Adelaide Hospital with serious but not life-threatening injuries.

The driver of the Ford SUV, which was towing a caravan, a 70-year-old woman from Queensland, was taken to Naracoorte Hospital for treatment of non-life-threatening injuries.

Following investigations, the Queensland woman was arrested on Sunday and charged with aggravated driving without due care causing harm and failing to give way.

She was bailed to appear in the Naracoorte Magistrates Court on 17 May.

Meanwhile, police are investigating a second serious crash on the region’s roads, which occurred at Reedy Creek on Monday morning.

Just before 10am police and SA Ambulance crews were called to the Princes Highway after reports of a two-car crash.

The driver of a 4WD, a 19-year-old man from Victoria, and his 14-year-old passenger were both taken to Kingston Hospital.

The driver was then airlifted to Adelaide in a serious condition.

The driver of a Kia, a man aged 42, and his passenger, a 41-year-old woman, both from Hove, were taken to Kingston Hospital with minor injuries.

Princes Highway was closed for several hours but reopened about 3pm.

Anyone who may have dashcam footage or witnessed the crash is asked to contact Crime Stoppers on 1800 333 000.