Three Mount Gambier men were arrested following a weekend pre-dawn brawl at a notorious Adelaide hot spot.

Police are investigating an altercation on Hindley Street at 5.10am on Sunday.

Officers and paramedics were called to the capital city street after reports a group of people were fighting.

An 18-year-old man was taken to hospital with non-life threatening injuries.

Three men were arrested at the scene; a 19-year-old and 20-year-old, both from Mount Gambier, were charged with affray.

Another 20-year-old Mount Gambier man, was charged with affray, assault cause harm and fail to state name.

They received barring orders and have been bailed to appear in the Adelaide Magistrates Court at a later date.

A 28-year-old Athol Park man was also arrested a short time later and charged with disorderly behaviour, loitering, breach of bail and resist arrest.

He was issued with a barring order and bailed to appear in court on March 28.

Investigations into the incident are ongoing.